rTMS Treatment for Fibromyalgia


A recent study has evaluated the efficacy of repetitive transcranial magnetic stimulation (rTMS) in treating fibromyalgia by targeting the prefrontal cortex. Participants were randomly assigned to receive either active rTMS or a placebo treatment, with their progress monitored over a period of six months.

Mechanism of Action

The prefrontal cortex is crucial for pain perception and emotional regulation. rTMS aims to modulate neural activity in this region, potentially alleviating pain and improving mood in fibromyalgia patients.


Participants in the active rTMS group underwent daily sessions over several weeks, where repetitive magnetic pulses were directed at the prefrontal cortex. The control group received a placebo treatment to account for the placebo effect.


The study found significant improvements in pain levels, mood, and overall quality of life among participants receiving active rTMS compared to the sham group. These benefits were observed not only immediately after the treatment period but also sustained over the six-month follow-up period.

Side Effects

The treatment was well-tolerated with minimal side effects. The most commonly reported side effects were mild headaches and scalp discomfort, which were temporary and resolved without intervention.


rTMS of the prefrontal cortex appears to be a promising treatment for fibromyalgia, offering significant and sustained improvements in pain and quality of life. Further research is needed to optimize treatment protocols and fully understand the long-term benefits and potential risks.

For more detailed information and specific study outcomes, please refer to the research paper titled “Repetitive transcranial magnetic stimulation of the prefrontal cortex for fibromyalgia syndrome: a randomised controlled trial with 6-months follow-up”. Research Paper